FtsK - a bacterial cell division checkpoint?
نویسندگان
چکیده
منابع مشابه
No SOS Needed: A Second Bacterial Checkpoint System Stops Cell Division
Cell division must be tightly coordinated with DNA replication so that a complete genome ends up in each daughter cell. That coordination is especially critical when DNA is damaged, as lengthy delays may be required to repair broken strands. To prevent premature division, cells detect the presence of broken DNA with dedicated sensor proteins, which inhibit division while they promote repair. In...
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Separating mitotic error correction, chromosome biorientation and the spindle assembly checkpoint (SAC) is complicated by their interconnected relationships. New research finds that Aurora B kinase, which drives error correction and promotes biorientation, also directly regulates the SAC.
متن کاملThe bifunctional FtsK protein mediates chromosome partitioning and cell division in Caulobacter.
Bacterial chromosome partitioning and cell division are tightly connected cellular processes. We show here that the Caulobacter crescentus FtsK protein localizes to the division plane, where it mediates multiple functions involved in chromosome segregation and cytokinesis. The first 258 amino acids of the N terminus are necessary and sufficient for targeting the protein to the division plane. F...
متن کاملAnalysis of molecular diffusion in ftsK cell-division mutants using laser surgery.
Escherichia coli cells that lack the carboxy-terminal part of FtsK fail to segregate their chromosomes properly during cytokinesis and tend to form chains. These chains are possibly formed as a result of DNA being trapped in the division planes or a failure to fuse the membrane during septum formation. If so, small molecules might diffuse between the apparent cell compartments. To investigate t...
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In natural environments, bacteria often adhere to surfaces where they form complex multicellular communities. Surface adherence is determined by the biochemical composition of the cell envelope. We describe a novel regulatory mechanism by which the bacterium, Caulobacter crescentus, integrates cell cycle and nutritional signals to control development of an adhesive envelope structure known as t...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2010
ISSN: 0950-382X
DOI: 10.1111/j.1365-2958.2010.07411.x